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《环境科学与工程前沿(英文)》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1604-5
● Metabolomic temporal profiling of cells exposed to xenobiotics.
关键词: Metabolomics BPA MCF-7 Temporal profiling Metabolic adaption Dysregulation correlation
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 231-241 doi: 10.1007/s11684-013-0253-7
Hepatocellular carcinoma (HCC) development is characterized by the presence of epigenetic alterations, including promoter DNA hypermethylation and post-translational modifications of histone, which profoundly affect expression of a wide repertoire of genes critical for cancer development. Emerging data suggest that deregulation of polycomb group (PcG) proteins, which are key chromatin modifiers repressing gene transcription during developmental stage, plays a causative role in oncogenesis. PcG proteins assemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2) to impose the histone H3 lysine 27 trimethylation (H3K27me3) modification for repression. In this review, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylation and histone modifications. Specifically, we will focus our discussion on the molecular roles of PcG proteins. Next, we will highlight recent findings on PcG proteins, their clinicopathological implication and their downstream molecular consequence in hepatocarcinogenesis. Last but not least, we will consider the therapeutic potential of targeting enhancer of zeste homolog 2 (EZH2) as a possible treatment for HCC. Improving our understanding on the roles of PcG proteins in hepatocarcinogenesis can benefit the development of epigenetic-based therapy.
关键词: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2)
Digital image correlation-based structural state detection through deep learning
《结构与土木工程前沿(英文)》 2022年 第16卷 第1期 页码 45-56 doi: 10.1007/s11709-021-0777-x
关键词: structural state detection deep learning digital image correlation vibration signal steel frame
Diagnosis method based on wavelet coefficient scale relativity correlation dimension for fault
GU Junjie, TIAN Jin, PENG Xuezhi
《能源前沿(英文)》 2008年 第2卷 第2期 页码 164-168 doi: 10.1007/s11708-008-0031-4
关键词: effective technology monitoring mechanical equipment relativity Correlation
Reliability analysis of urban gas transmission and distribution system based on FMEA and correlation
Su LI,Weiguo ZHOU
《能源前沿(英文)》 2014年 第8卷 第4期 页码 443-448 doi: 10.1007/s11708-014-0336-4
关键词: gas transmission and distribution system risk evaluation reliability analysis failure mode and effects analysis (FMEA) correlation operator
Measurement and correlation of the solid-liquid equilibrium of 2-(
Yanhong SUN, Zhiyong LI, Chuang XIE, Wei CHEN, Cui ZHANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 110-115 doi: 10.1007/s11705-013-1316-7
关键词: solid-liquid equilibrium (SLE) eutectic integrated computer aided system (ICAS) TOPEM correlation
Deformation field and crack analyses of concrete using digital image correlation method
Yijie HUANG, Xujia HE, Qing WANG, Jianzhuang XIAO
《结构与土木工程前沿(英文)》 2019年 第13卷 第5期 页码 1183-1199 doi: 10.1007/s11709-019-0545-3
关键词: deformation filed distribution crack development digital image correlation method mechanical properties water-cement ratio characteristics of deformation and crack
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 247-252 doi: 10.1007/s11684-017-0519-6
The activity of free radicals in follicular fluid was related to ovarian responsiveness, in vitro fertilization (IVF), and embryo transfer success rate. However, studies analyzing the relationship between the free radical scavenging capacity and embryo quality of infertile women with polycystic ovarian syndrome (PCOS) were lacking. The aim of this study was to evaluate the relationship between the free radical scavenging window of women with PCOS and their embryo quality. The free radical scavenging capacity of follicular fluid from women with PCOS was determined by a,a-diphenyl-b-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) assay, superoxide radical, and reactive oxygen species (ROS) assay. In the DPPH and ROS assays, the follicular fluid from grades I and II embryos was significantly higher than the follicular fluid from grades III and IV embryos. The lower control limit of DPPH radical scavenging capacity and upper control limit of ROS level were 13.2% and 109.0 cps, respectively. The calculated lower control limit and upper control limit were further confirmed in the follicular fluid of embryos of all grades. These cut-off values of free radical scavenging activity of follicular fluid could assist embryologists in choosing the development of embryos in PCOS patients undergoing IVF.
关键词: in vitro fertilization PCOS free radical embryo quality
Luxi Zou, Huaibo Li, Shuo Wang, Kaikai Zheng, Yan Wang, Guocheng Du, Ji Li
《环境科学与工程前沿(英文)》 2019年 第13卷 第6期 doi: 10.1007/s11783-019-1167-7
关键词: Taihu Basin Wastewater treatment plant Influent characteristics Energy consumption evaluation Specific energy consumption SPSS correlation analysis
Correlation analysis of couple optical paths for micro stereovision with stereo light microscope
WANG Yuezong, LI Desheng, YU Yaping
《机械工程前沿(英文)》 2007年 第2卷 第3期 页码 288-292 doi: 10.1007/s11465-007-0050-6
关键词: intension micromanipulation correlation function objective quantified
《环境科学与工程前沿(英文)》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1548-1
• Water-dispersible nano-pollutions exhibit type-specific toxic effects on E. coli.
关键词: Nano-toxicity Nano-plastics Quantum dots Microbial metabolite Metabolic dysregulation
A new heat transfer correlation for supercritical fluids
Yanhua YANG, Xu CHENG, Shanfang HUANG
《能源前沿(英文)》 2009年 第3卷 第2期 页码 226-232 doi: 10.1007/s11708-009-0022-0
关键词: super critical fluids heat transfer circular tubes prediction method
JIANG Tong, CHEN Laiyun, XING Hailing, L? Xilin
《结构与土木工程前沿(英文)》 2007年 第1卷 第4期 页码 430-435 doi: 10.1007/s11709-007-0058-3
关键词: surface ground horizontal uniform Finally seismic ground correlative seismic
Xiao-ping BAI,Ya-nan LIU
《结构与土木工程前沿(英文)》 2016年 第10卷 第4期 页码 462-471 doi: 10.1007/s11709-016-0361-y
关键词: civil engineering dynamic reliability grey relational degree adaptive simulated annealing algorithm
标题 作者 时间 类型 操作
Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A
期刊论文
Diagnosis method based on wavelet coefficient scale relativity correlation dimension for fault
GU Junjie, TIAN Jin, PENG Xuezhi
期刊论文
Reliability analysis of urban gas transmission and distribution system based on FMEA and correlation
Su LI,Weiguo ZHOU
期刊论文
Measurement and correlation of the solid-liquid equilibrium of 2-(
Yanhong SUN, Zhiyong LI, Chuang XIE, Wei CHEN, Cui ZHANG
期刊论文
Deformation field and crack analyses of concrete using digital image correlation method
Yijie HUANG, Xujia HE, Qing WANG, Jianzhuang XIAO
期刊论文
Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with
null
期刊论文
Characteristic and correlation analysis of influent and energy consumption of wastewater treatment plants
Luxi Zou, Huaibo Li, Shuo Wang, Kaikai Zheng, Yan Wang, Guocheng Du, Ji Li
期刊论文
Correlation analysis of couple optical paths for micro stereovision with stereo light microscope
WANG Yuezong, LI Desheng, YU Yaping
期刊论文
Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic and bacteriological investigation in
期刊论文
Seismic ground motion analysis of Shanghai Pudong Airport site considering the effects of spatial correlation
JIANG Tong, CHEN Laiyun, XING Hailing, L? Xilin
期刊论文